CDH1 and posterior cortical atrophy: To further assess the role of E-cadherin in the chemoresistance of PCa cells, two different E-cadherin siRNAs were used to silence E-cadherin expression in PC3 and DU145 cells (si-E-cadherin-1, target sequence 2370–2389; si-E-cadherin-2, target sequence 800–818).