Furthermore, we also revealed that CXCL5 secreted by tumor cells was able to promote CRC migration through ERK/Elk-1/Snail-mediated EMT (Epithelial mesenchymal transition) and invasion via the AKT/GSK3β/β-catenin/MMP7 pathway in a CXCR2-dependent manner. The gene discussed is CXCL5; the disease is colorectal carcinoma.