Ednrb is one such gene responsible for distinctive coat color phenotypes in various species, for example, Waardenburg syndrome type 4 (WS4) in humans [4], aganglionosis in rats [5–7], piebald-lethal in mice [8], Lethal White Foal Syndrome in horses [9], and panda plumage color phenotype in Japanese quails [10], some of these species possess a characteristic head spot. The gene discussed is EDNRB; the disease is Waardenburg-Shah syndrome.