The multivariate analysis of a cohort of 239 Brazilian patients chronically infected with HCV showed that the GT/TT genotype of the MTTP -493G/T SNP (rs1800591) was associated with hepatic steatosis in patients infected with HCV genotype 3, in a total cohort of 239 Brazilian patients chronically infected with HCV, including 198 patients infected with HCV genotype non-3 and 41 infected with HCV genotype 3. Here, MTTP is linked to fatty liver disease.