The rTg4510 transgenic mouse line, in which the P301L-mutated human tau (MAPT) gene that causes Frontotemporal Dementia with Parkinsonism-17 is expressed in excitatory neurons of the forebrain, recapitulates many characteristics of neurodegenerative disease (Ramsden et al., 2005, Santacruz et al., 2005). This evidence concerns the gene MAPT and neurodegenerative disease.