This is a non-hypermutated group with multiple somatic copy number alterations, and aneuploidy by recurrent missegregation of whole chromosomes during cell division [3,4], containing oncogenic activation of KRAS and PIK3CA and mutation and loss of heterozygosity of tumor suppressor genes such as APC and TP53; and CpG Island Methylator Phenotype (CIMP) CRCs in 20% that overlap greatly with MSI CRC and some non-hypermutated CRC [2]. The gene discussed is APC; the disease is colorectal carcinoma.