We searched for the optimal cut-off values to maximize the difference in lung function, setting the cut-off values to cluster IPF patients into high and low groups at 15.0 ng/mL for monomeric periostin, 100 ng/mL for total periostin, 1,000 IU/mL for KL-6, 220 ng/mL for SP-D, and 240 IU/mL for LDH. The gene discussed is POSTN; the disease is idiopathic pulmonary fibrosis.