In order to confirm our hypothesis, we established Annexin A1-up-regulated 5-8F NPC cell line and Annexin A1-down-regulated 6-10B NPC cell line and analyzed the effects of Annexin A1 modulation on the expression of Vimentin and S100A9 and in vitro NPC cell invasion. Here, ANXA1 is linked to nasopharyngeal carcinoma.