COG2 and early-onset autosomal dominant Alzheimer disease: Our bioinformatic studies also indicate that the COG2 subunit is one of 42 gene products present in the ATP7A interactome associated with tauopathies and Alzheimer’s disease; one of fourteen genes products associated with Parkinson’s disease; and one of the 49 gene products in the ATP7A interactome associated with neurocognitive disorders, such as dementia (Figure 3).