ANGPT2 and neoplasm: Vegfa, the angiopoietin receptor TIE2 (gene name Tek), the endothelial marker CD31 (Pecam1 as the gene name) and the angiogenesis marker tumor endothelial marker-8 (TEM8, Antxr1) are all significantly up-regulated in Adipo-ANG2 transgenic mice, indicating that the local angiogenic program is activated upon ANG-2 induction (Figure 2A).