The most dysregulated lncRNAs—namely ENST00000563280 (osteosarcoma doxorubicin-resistance related upregulated lncRNA, ODRUL) and NR-036444—were critical for doxorubicin resistance due to their interactions with important genes including: ATP-binding cassette, subfamily B, member 1 (ABCB1), HIF-1α and forkhead box protein C2 (FOXC2) [83]. This evidence concerns the gene ABCB1 and osteosarcoma.