SERPINE1 and type 2 diabetes mellitus: These studies show that an oat bran diet (102 g/day of oat bran added to a low-fiber diet) for two weeks lowered PAI-1 concentrations compared with a low-fiber diet in 24 young healthy subjects [38] and a low-GI diet reduced PAI-1 concentrations in 20 patients with T2DM [11], 12 men with T2DM [39] and 50 overweight women [40].