It is reported by our group that fructose induces dysregulation of renal organic ion transporters including GLUT9, renal specific transporter (RST), organic anion transporter 1 (OAT1), OAT3, and urate transporter (UAT), which cause abnormal renal UA excretion involved in hyperuricemia and renal dysfunction [114]. Here, SLC22A12 is linked to hyperuricemia.