In a cross sectional study on 50 patients suffering from IPF, we have recently shown that IGFBP-1 and IGFBP-2 are increased in newly diagnosed IPF and IGFBP-2 reduced in patients treated with anti-fibrotic therapy though still raised as compared to healthy subjects [20]. Here, IGFBP1 is linked to idiopathic pulmonary fibrosis.