EPAC-1 expression levels associated with miR-7-5p expression levels to a high extend (r2 = 0.464, p < 0.001, Fig. 5c) indicating that the hypoxia-induced expression of miR-7 might underlie the loss of EPAC-1 expression in diabetic retinopathy. The gene discussed is RAPGEF3; the disease is diabetic retinopathy.