For example, in a cohort of patients with familial hypercholesterolaemia, hypermethylation of the promoter region of ATP-binding cassette A1 (ABCA1), which encodes a protein involved in cholesterol transfer from blood to high-density lipoprotein (HDL) particles, was found to be associated with lower levels of HDL-cholesterol and with prior history of coronary artery disease (CAD) (Guay et al. 2012). The gene discussed is ABCA1; the disease is coronary artery disorder.