ZEB2, but not ZEB1, together with NF-κB seems to control the transcriptional regulation of SOD2. In addition, a positive feedback loop has been described between SOD2 and NF-κB during EMT in lung adenocarcinoma cells: NF-κB can promote SOD2 transcriptional activation and concomitantly SOD2 induces EMT activating the axis NF-κB/IκB kinase β (IKKβ) (181). Here, SOD2 is linked to lung adenocarcinoma.