VIM and hepatocellular carcinoma: Silencing of ME1 in hepatocellular carcinoma cells inhibits migration and invasion by blocking the EMT program (i.e., restoring E-cadherin while downregulating N-cadherin and vimentin expression) in a ROS-dependent way, suggesting ME1 as a poor prognostic predictor for hepatocellular carcinoma-bearing patients (231).