Notably, the PGC-1α-induced metabolic conversion toward OXPHOS is synergistically coupled to a functional EMT program and although PGC-1α-induced pathways are not essential for cancer cells during the acquisition of a mesenchymal phenotype, both pathways concur and correlate with the achievement of invasive and metastatic properties (153). The gene discussed is PPARGC1A; the disease is cancer.