GLS inhibitors have shown positive results in preclinical models; bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl) ethyl sulfide impairs cancer cells growth in vitro and in vivo (125, 126), the GLS inhibitor CB-839 is effective against triple-negative breast cancer (TNBC) and hematological tumors in preclinical studies (127, 128) and is currently moved on to clinical trials (129). The gene discussed is GLS; the disease is cancer.