These findings concur with SAPiT [23], CAMELIA [24], and STRIDE [25] clinical trials which informed WHO guidance and collectively demonstrated that early initiation of ART can reduce mortality and AIDS progression, notwithstanding the risk of increased immune reconstitution inflammatory syndrome (IRIS) in patients with active TB and with very low CD4 cell counts (i.e., <50 cells/mL). This evidence concerns the gene CD4 and tuberculosis.