Chronic kidney disease and cardiovascular disease are related to hypertension, dyslipidemia and endothelial dysfunction and the cardiorenal syndrome represents a complex molecular interplay of neurohumoral pathway activation, the renin angiotensin aldosterone axis, vascular inflammation, oxidative stress, cardiac hypertrophy and fibrosis in the heart and kidneys [26, 27]. This evidence concerns the gene REN and endothelial dysfunction.