The results showed that hazard ratios for diabetes mellitus, 4G/4G of PAI-1 gene and DD of ACE gene were high and statistically significant, p = 0.003, p = 0.009, p = 0.005, respectively, these three factors were the independent prognostic factors for MACE in CAD patients (Table 6). This evidence concerns the gene SERPINE1 and diabetes mellitus.