Moreover, studies performed by Jain et al. also indicated the appearance of ZAG in the albumin-negative urine samples subsequently preceded the appearance of albumin in T2DM patients of South Asian Indians, suggesting that ZAG may be an earlier novel urinary biomarker useful for the screening of nonalbuminuric diabetic nephropathy [20]. The gene discussed is AZGP1; the disease is type 2 diabetes mellitus.