INS and obesity due to melanocortin 4 receptor deficiency: Yeung et al. demonstrated that serum ZAG levels were markedly elevated in overweight/obesity, hypertension, hypertriglyceridemia, or T2DM in south Chinese subjects, and serum ZAG also significantly associated the obesity-related parameters (WC and BMI), insulin resistance (increased fasting insulin, increased HOMA-IR), and increased TG levels [27].