Recent studies performed by Rao et al. demonstrated that urine ZAG levels were progressively increased across three categories of diabetic patients with normo-, micro-, and macroalbuminuria by a robust 2-D DIGE approach coupled with LCMS/MS in Indian T2DM patients, indicating that it is positively related with diabetes nephropathy progression [8]. The gene discussed is AZGP1; the disease is diabetic kidney disease.