Aberrant activation of Th17 cells and their effector cytokines IL-17A and GM-CSF are implicated in the pathogenesis of various autoimmune and inflammatory diseases such as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, dermatomyositis, allergy, asthma, and others (2). The gene discussed is IL17A; the disease is systemic lupus erythematosus.