TNNI3 and familial dilated cardiomyopathy: In addition to D75Y and E59D, the G159D cTnC mutation has been found in human DCM patients and has been shown to impair cTnC-cTnI interaction and decrease Ca2+ binding affinity (Mogensen et al., 2004; Biesiadecki et al., 2007; Robinson et al., 2007; Baryshnikova et al., 2008).