Four rare clinical variates (Y5H, M103I, D145E, and I148V) of TnnC1 have been reported in association with DCM (Hershberger et al., 2010), of which Y5H cTnC mutation was reported in a pediatric patient with idiopathic DCM concomitant with a mutation in Myosin (Rampersaud et al., 2011). This evidence concerns the gene TNNC1 and familial dilated cardiomyopathy.