Emerging data demonstrates that in the lung tissue and fibroblasts of IPF patients, there is a reduction of Cav-1 expression relative to the control samples (Wang et al., 2006); as well as in the lung tissues of patients with skin scleroderma (Del Galdo et al., 2008; Tourkina et al., 2008; Gvaramia et al., 2013). This evidence concerns the gene CAV1 and idiopathic pulmonary fibrosis.