AVD has been observed when death receptors, such as CD95, are engaged in human lymphoid (U937), human epithelial (HeLa), mouse neuroblastoma/rat glioma hybrid (NG108-15), and rat phaeochromocytoma (PC12) cells (Okada and Maeno, 2001) and in mouse fibroblasts as demonstrated by the present study. The gene discussed is FAS; the disease is central nervous system cancer.