Finally, apigenin is also responsible for NAG-1 [Nonsteroidal Anti-inflammatory Drug (NSAID) Activated Gene-1] overexpression in CRC cells, a member of the TGF-B (Transforming Growth Factor-B) superfamily which shows pro-apoptotic and antitumor activities (Yang et al., 2014). Here, GDF15 is linked to colorectal carcinoma.