MCL1 and neoplasm: As apigenin induces apoptosis in tumor cells by modulating different kinds of signaling pathways, including downregulation of Mcl-1 mRNA (Shi et al., 2015), this apigenin Mcl-1 downregulation may enhance the ABT-263 antitumor activity (Shao et al., 2013; Erdogan et al., 2016).