There was significant difference in the levels of the following complement system proteins released in plasma circulating MPs between the malaria samples and that of control: complement component C6, complement C4-B, complement component C9, complement factor B and Complement C1q subcomponent subunit C. The difference between the patients and the control group in complement component C3 was however not significant but correlation analysis indicated a significant negative correlation between C3 released in MPs and parasite count in the malaria samples. The gene discussed is C3; the disease is malaria.