Reikvam et al. reported that CX45 expression show a wide variation between human myeloid leukemia cells at the mRNA level and a high CX45 expression was associated with the altered regulation of the mitogen-activated protein kinase (MAPK) pathway, whereas a low CX45 expression was associated with the altered regulation of protein functions42. This evidence concerns the gene GJC1 and myeloid leukemia.