Moreover, Verma et al. report increased Shp2 tyrosine phosphorylation, and possibly activity, in mouse kidneys after protamine sulfate-induced injury and in a subset of human glomerular diseases (minimal change nephrosis and membranous nephropathy but not in focal segmental glomerulosclerosis)14. The gene discussed is PTPN11; the disease is focal segmental glomerulosclerosis.