CGD patients are more prone to a variety of autoimmune manifestations including inflammatory bowel disease and systemic lupus erythematosus (SLE; Singel and Segal, 2016), whereas polymorphic variation in components of the phagocyte NADPH oxidase machinery can play a role in the pathogenesis of polygenic autoinflammatory disease. Here, FMO5 is linked to chronic granulomatous disease.