NRROS and bacterial infectious disease: Deficiency of Nrros in mice causes increased expression of the gp91phox-p22phox heterodimer with a concomitant increase in the magnitude of the phagocyte respiratory burst that has beneficial effects for clearance of bacterial infection but detrimental in that it leads to a more severe disease course of experimental allergic encephalomyelitis (Noubade et al., 2014).