In contrast, several neuropathology studies failed to detect a strong correlation of the different DPR species (or RNA foci) with the region‐specific neurodegeneration seen in C9orf72 ALS and FTLD patients (Mackenzie et al, 2013; Schludi et al, 2015), suggesting an interplay of several factors and/or non‐cell autonomous effects such as spreading and seeding may be crucial for pathogenesis. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.