In this study, we confirmed the significant negative correlation between SnoN and TGF-β1, designed two strategies of SnoN upregulation (knocking down a negative regulator of SnoN or introducing exogenous copies of SnoN), and demonstrated the suppression of renal tubular cell EMT due to SnoN upregulation, which would consequently result in protection from renal fibrosis. This evidence concerns the gene SKIL and renal fibrosis.