To examine the responsiveness of prostate cancer cells to the cytotoxic effects of single drug loaded micelles (docetaxel, rapamycin, 17-AAG), PTEN-P2 (Fig 1D, 1E and 1F) and PTEN-CaP2 (Fig 1G, 1H and 1I) were treated with increasing doses of single drug loaded micelle from 10nM to 10μM. This evidence concerns the gene PTEN and Familial prostate cancer.