For example, Wang et al. found that low claudin-6 expression indicate a worse prognosis in patients with non-small cell lung cancer [33] and Li et al. showed that high expression of claudin-1 had a poorer prognosis than those with low expression in patients with hypopharyngeal squamous cell carcinoma [34]. This evidence concerns the gene CLDN1 and hypopharynx squamous cell carcinoma.