MYC and glioblastoma: Indeed, since ΔMax* does not bind non-specific DNA but preferentially heterodimerizes with c-Myc* and binds to the E-box sequence and non-specific DNA with comparable affinities, its overexpression in GBM cells can be anticipated to increase the amount of c-Myc at E-box sequences and non-specific sites, thereby increasing c-Myc transcriptional activities and induction of proliferation.