As Fig 5A, 5C and 5D shown, the expression levels of ATP2B4 (P<0.05), ROR1 (P<0.05) and PRKCB (P<0.05) were significantly down-regulated and NR3C1 (Fig 5B) was down-regulated in READ compared to adjacent non-tumor tissues. Here, ATP2B4 is linked to neoplasm.