CLU and Alzheimer disease: Other genetic factors may also play a role, such as variants in ATP binding cassette subfamily A member 1 (ABCA1) that are genome-wide significant risk variants for both LDL-C concentration and AD; additional AD risk variants are located near genes involved in lipid metabolism, such as sortilin-related receptor L1 (SORL1), clusterin (CLU), ATP binding cassette subfamily A member 7 (ABCA7), phosphatidylinositol-binding clathrin assembly protein (PICALM), and bridging integrator 1 (BIN1) [55,56].