Bleomycin and doxorubicin increased cell death receptor expression in p53-wild type HepG2 and in p53-deficient Hep3B cells suggesting that p53, TAp63 and TAp73 can trigger expression of cell death receptors and consequently sensitize HCC cells toward apoptosis induced by DNA-damaging drugs [12]. Here, TP53 is linked to hepatocellular carcinoma.