The development of HCC in the context of liver cirrhosis is associated with different co-morbidities, high pro-inflammatory component, oxidative/nitrosative stress and alternation of cell death and proliferation cycles which have been related to genetic and epigenetics alterations affecting relevant intracellular signaling related to epidermal growth factor receptor (EGFR), Ras/extracellular regulated signal ERK, phosphoinositol 3-kinase (PI3K)/ mammalian Target of Rapamycin (mTOR), epithelial-mesenchymal transition factor (c-met), Wnt, Hedgehog, and inactivation of apoptotic signaling [17]. Here, EGFR is linked to hepatocellular carcinoma.