In agreement with this observation, Flores et al. [19] showed that p73+/- (and p63+/-) heterozygous animals develop thymic lymphomas, hemangiosarcomas, lung adenomas, squamous cell carcinoma and histiocytic sarcomas, whereas HCC was only observed at 15% in double heterozygous p53+/-:p73+/- mice. This evidence concerns the gene TP53 and hepatocellular carcinoma.