Of note, Sdc1 deficient (Sdc1-KO) mice exhibit an enhanced inflammatory phenotype in a model of chemically induced acute colitis as evidenced by enhanced leukocyte infiltration, increased levels of inflammatory cytokines and adhesion molecules, and increased mortality [27]; however the effect of Sdc1 deficiency on chronic colitis was not investigated until recently. Here, SDC1 is linked to Chronic colitis.