In a total of over 11,000 individuals, we found evidence suggesting that the five-allele HLA haplotype A*03:01~B*07:02~DRB1*15:01~DQA1*01:02~DQB1*06:02 is a risk factor for AD and that this effect may be driven by men who do not carry the major AD risk factor, APOE ɛ4. Here, APOE is linked to Alzheimer disease.