VEGFA and major depressive disorder: Elevated docosahexanoic acid can antagonize arachidonic acid, which is tumorigenic in nature, and increases the release of the fatty acid derivative neuroprotectin D1, which may mediate PEDF's neurotrophic and anti-inflammatory activities.31 PEDF is also known to be antiangiogenic and antitumorigenic, and to function in tissue homeostasis.46 This appears to occur through a counterbalance with vascular endothelial growth factor, which is pro-angiogenic47 and has previously been implicated in depression.48 Notably, PEDF is downregulated in many cancers.31