TWIST1 and colorectal cancer: Besides the functions of promoting cell cycle, mitosis and cell proliferation to initiate colorectal cancer development, Wnt/β-catenin signaling pathway also involves in epithelial-mesenchymaltransition (EMT), the later is an early event of invasion and metastasis, through up-regulating EMT-associated transcription factors Snail, Twist and ZEB1 [4,25].