CXCL8 and colorectal cancer: The second module/cluster (Figure 4C) is mainly consisted of C-X-C Motif Chemokine Ligend (CXCL) family members CXCL1, CXCL2, CXCL6, CXCL8 and CXCL12. The up-regulation of chemokine and cytokines expression are the major characteristics of inflammation-associated colorectal cancer [26,27].