It has been demonstrated that stimulation of TLR4 with Echerichia coli LPS for 24 h in TLR4-positive gastric cancer cell lines, including BGC-823 and SGC-7901, induced production of mitochondrial ROS, AKT phosphorylation and RelA nuclear translocation, and enhanced proliferation without affecting apoptosis [100]. This evidence concerns the gene RELA and gastric cancer.