PIK3CD and B-cell chronic lymphocytic leukemia: Finally, as p110δ/γ are primarily expressed by leukocytes and the inhibitors of these subunits (such as those recently investigated in CLL and lymphoma [132]) have the potential to reverse some of the protective effects of the BMM, it appears that isoform-specific inhibition of p110δ and/or γ hold the most promise in haemic malignancies.