However, recent studies revealed additional mutations involved in growth and progression of malignant melanoma, e.g., KIT proto-oncogene receptor tyrosine kinase (KIT) gene in mucosal melanoma, telomerase reverse transcriptase (TERT) gene, germline cyclin dependent kinase inhibitor 2A (CDKN2A) gene, tumor protein p53 (TP53) gene, neurofibromin 1 (NF1) gene and others [13,14,15]. The gene discussed is NF1; the disease is melanoma.