For example, SLC1A5 takes up l-glutamine which is then exchanged for mTOR-activating l-leucine and other essential amino acids via the bidirectional antiporter SLC7A5, and both SLC1A5 and SLC7A5 are overexpressed in cancers along with glutamine transporter, SLC6A14 [52]. The gene discussed is SLC6A14; the disease is cancer.