In fact, Shao et al. have recently shown that serum 25OH-D3 negatively correlates with VEGF in diabetic patients; such correlation suggests that the protective effects of vitamin D in terms of decreasing proteinuria and delaying the progression of diabetic kidney disease may be mediated through its suppression of abnormal angiogenesis, inflammation, and vascular endothelial dysfunction [19]. The gene discussed is VEGFA; the disease is diabetic kidney disease.