HVCN1 and B-cell chronic lymphocytic leukemia: In addition, there is one report showing that proton (HVCN1) channels in B cells have two potential start codons and there is different expression pattern between healthy controls and patients with chronic lymphocytic leukemia (CLL): the full-length HVCN1 channel expresses more in healthy controls while the shorter HVCN1 channel, which lacks 20 amino acids in the N-terminus, expresses more in CLL patients44.