PIK3CA and neoplasm: Previously, plenty of efforts have been done to develop new inhibitors of the PI3K-Akt pathway, which always target key regulatory proteins such as PTEN29, PDK147, Akt48 or PI3K49, since increasing evidence has been validated that blocking the PI3K-Akt pathway could simultaneously inhibit the proliferation and growth of tumor cells and sensitize them toward programmed cell death27.