Recently, an essential role of HSP-mediated cytoskeletal repair in a Caco-2 model of celiac disease was observed, as a shift of HSP70 from the cytoplasmic fraction into the cytoskeletal fraction of Caco-2 cells, resulted in the maintenance of barrier integrity through stabilization of E-cadherin protein [45]. The gene discussed is HSP90B2P; the disease is celiac disease.