TNFSF10 and cancer: Because TRAIL‐binding death receptors are generally overexpressed in cancer cells compared to healthy cells, and because PBAE‐based nanoparticles demonstrate biomaterial‐mediated cancer specificity, we hypothesized that the combination would lead to enhanced cancer‐specific cell death.25 In this study, we engineered PBAE/DNA nanoparticles for gene delivery to several cancer cell types and examined their specificity for transfection of cancer cells over healthy cells derived from non‐cancerous tissue of the same type.