In addition to biomaterial‐mediated specificity for cancer cells, gene therapy can utilize downstream transcriptional targeting and specialized protein activity to target and kill cancer cells, such as through the exogenous expression of a cytotoxic protein.24 We sought to evaluate cancer cell survival in vitro in response to polymeric delivery of the apoptotic gene tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL), which binds to death receptors on the cell surface to trigger cell death. Here, TNF is linked to cancer.